@inproceedings{9eb492b9989743349ee7bf35e2f30921,
title = "Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema",
abstract = "We used spatially modulated near-infrared (NIR) light to detect and map chromophore changes during cerebral edema in the rat neocortex. Cerebral edema was induced by intraperitoneal injections of free water (35\% of body weight). Intracranial pressure (ICP) was measured with an optical fiber based Fabry-Perot interferometer sensor inserted into the parenchyma of the right frontal lobe during water administration. Increase in ICP from a baseline value of 10 cm-water to 145 cm-water was observed. Following induction of cerebral edema, there was a 26±1.7\% increase in tissue concentration of deoxyhemoglobin and a 47±4.7\%, 17±3\% and 37±3.7\% decrease in oxyhemoglobin, total hemoglobin concentration and cerebral tissue oxygen saturation levels, respectively. To the best of our knowledge, this is the first report describing the use of NIR spatial modulation of light for detecting and mapping changes in tissue concentrations of physiologic chromophores over time in response to cerebral edema.",
keywords = "Brain injury, Cerebral hemodynamics, Edema, Intracranial pressure, Optical properties, Spatially modulate light",
author = "David Abookasis and Mathews, \{Marlon S.\} and Owen, \{Christopher M.\} and Binder, \{Devin K.\} and Linskey, \{Mark E.\} and Frostig, \{Ron D.\} and Tromberg, \{Bruce J.\}",
year = "2008",
month = feb,
day = "7",
doi = "10.1117/12.760516",
language = "אנגלית",
isbn = "9780819470171",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
address = "ארצות הברית",
note = "Photonic Therapeutics and Diagnostics IV ; Conference date: 19-01-2008 Through 19-01-2008",
}