The sirtuin SIRT6 regulates lifespan in male mice

Keyphrases

• Age-related Illnesses 20%
• Deacetylases 20%
• Family Members 20%
• Gene Expression Analysis 20%
• Growth Factors 40%
• Healthy Aging 20%
• Human Lifespan 20%
• Insulin-like 40%
• Insulin-like Growth Factor Binding Protein (IGFBP) 20%
• Long Lifespan 20%
• Low Serum 20%
• Major Components 20%
• Male Mice 100%
• Medical Challenges 20%
• Mice Transgenic 20%
• Nematodes 20%
• Overexpressing 20%
• Phosphorylation State 20%
• Serum Levels 20%
• Sir2 20%
• SIRT7 20%
• Sirtuin 1 (SIRT1) 20%
• Sirtuin 6 (SIRT6) 100%
• Sirtuin Family 20%
• Sirtuins 100%
• Therapeutic Implications 20%
• Transgenic Mice 40%
• Wild Mice 40%
• Worm 20%

Biochemistry, Genetics and Molecular Biology

• Binding Protein 12%
• Blood Level 12%
• Gene Expression Profiling 12%
• Healthy Aging 12%
• Insulin-Like Growth Factor 1 25%
• Lifespan 100%
• Nematode 12%
• Sir2 12%
• SIRT6 100%
• SIRT7 12%
• Sirtuin 100%
• Sirtuin1 12%
• Synapsin I 12%
• Transgenic Mouse 25%
• Transgenics 12%
• Wild Type Mouse 25%

Neuroscience

• Expression Analysis 16%
• Gene Expression 16%
• Insulin-Like Growth Factor 1 33%
• Protein Binding 16%
• Sirtuin 100%
• Synapsin I 16%