TY - JOUR
T1 - The safety of histamine 2 (H2) blockers in pregnancy
T2 - A meta-analysis
AU - Gill, Simerpal Kaur
AU - O'Brien, Lisa
AU - Koren, Gideon
N1 - Funding Information:
Acknowledgment Motherisk NVP helpline is supported by an unrestricted grant from Duchesnay, Inc. Canada. GK is holder of the Research Leadership for Better Pharmacotherapy during Pregnancy and Lactation (Hospital for Sick Children) and the Ivey Chair in Molecular Toxicology (Department of Medicine, University of Western Ontario).
PY - 2009/9
Y1 - 2009/9
N2 - Heartburn and acid reflux increase the severity of nausea and vomiting of pregnancy, and may lead to more serious medical conditions. The fetal safety of histamine 2 (H2) blockers, the most common antireflux medication, during pregnancy needs to be determined. The aim herein is to determine the fetal safety of H2 blockers during pregnancy through systematic review. All original research assessing the safety of H2 blockers in pregnancy was sought. Data included congenital malformations, spontaneous abortions, preterm delivery, and small for gestational age. A random-effects model combined results. With data from 2,398 exposed and 119,892 nonexposed to H2 blockers, overall odds ratio was 1.14 [0.89, 1.45]. Further analysis revealed no increased risks for spontaneous abortions, preterm delivery, and small for gestational age with odds ratios and 95% confidence intervals (CIs) of 0.62 [0.36-1.05], 1.17 [0.94, 1.147], and 0.28 [0.06, 1.22], respectively. H2 blockers can be used safely in pregnancy.
AB - Heartburn and acid reflux increase the severity of nausea and vomiting of pregnancy, and may lead to more serious medical conditions. The fetal safety of histamine 2 (H2) blockers, the most common antireflux medication, during pregnancy needs to be determined. The aim herein is to determine the fetal safety of H2 blockers during pregnancy through systematic review. All original research assessing the safety of H2 blockers in pregnancy was sought. Data included congenital malformations, spontaneous abortions, preterm delivery, and small for gestational age. A random-effects model combined results. With data from 2,398 exposed and 119,892 nonexposed to H2 blockers, overall odds ratio was 1.14 [0.89, 1.45]. Further analysis revealed no increased risks for spontaneous abortions, preterm delivery, and small for gestational age with odds ratios and 95% confidence intervals (CIs) of 0.62 [0.36-1.05], 1.17 [0.94, 1.147], and 0.28 [0.06, 1.22], respectively. H2 blockers can be used safely in pregnancy.
KW - Acid reflux
KW - GERD
KW - H2 blockers
KW - Malformations
KW - Pregnancy
UR - https://www.scopus.com/pages/publications/68249158530
U2 - 10.1007/s10620-008-0587-1
DO - 10.1007/s10620-008-0587-1
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C2 - 19051023
AN - SCOPUS:68249158530
SN - 0163-2116
VL - 54
SP - 1835
EP - 1838
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 9
ER -