The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis

Eun Jeong Choi, Nae Ry Kim, Ho Seok Kwak, Kyoung Chul Chun, Young Ah Kim, Jae Whoan Koh, Jung Yeol Han, Sung Hong Joo, Ji Sung Lee, Gideon Koren

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

8 ציטוטים ‏(Scopus)

תקציר

Objective Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systematic review and meta-analysis. Methods Eligible studies were searched and identified using various databases. Single-arm meta-analysis and meta-analysis of odd ratios among controlled studies were performed using Review Manager version 5.3. Results Ten eligible studies that combined 2,783 isotretinoin-exposed women were included in our study. The rate of MM weighted for the sample size was 15%. Three studies that included an unexposed comparison group were eligible for the meta-analysis. The pooled odds ratio of MM for isotretinoin-exposed women was 3.76. After 2006, the pooled odds ratio of MM for isotretinoin exposure was significantly lower at 1.04. Conclusion The current rate of MM in isotretinoin-exposed women was substantially lower after 2006.

שפה מקוריתאנגלית
עמודים (מ-עד)364-373
מספר עמודים10
כתב עתObstetrics and Gynecology Science
כרך64
מספר גיליון4
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 2021

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