The dynamics of HMG protein-chromatin interactions in living cells

Gabi Gerlitz, Robert Hock, Tetsuya Ueda, Michael Bustin

פרסום מחקרי: פרסום בכתב עתסקירהביקורת עמיתים

76 ציטוטים ‏(Scopus)

תקציר

The dynamic interaction between nuclear proteins and chromatin leads to the functional plasticity necessary to mount adequate responses to regulatory signals. Here, we review the factors regulating the chromatin interactions of the high mobility group proteins (HMGs), an abundant and ubiquitous superfamily of chromatin-binding proteins in living cells. HMGs are highly mobile and interact with the chromatin fiber in a highly dynamic fashion, as part of a protein network. The major factors that affect the binding of HMGs to chromatin are operative at the level of the single nucleosome. These factors include structural features of the HMGs, competition with other chromatin-binding proteins for nucleosome binding sites, complex formation with protein partners, and post-translational modifications in the protein or in the chromatin-binding sites. The versatile modulation of the interaction between HMG proteins and chromatin plays a role in processes that establish the cellular phenotype.

שפה מקוריתאנגלית
עמודים (מ-עד)127-137
מספר עמודים11
כתב עתBiochemistry and Cell Biology
כרך87
מספר גיליון1
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - פבר׳ 2009
פורסם באופן חיצוניכן

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