Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

Alex M. Szpilman; Jeffrey M. Manthorpe; Erick M. Carreira

doi:10.1002/anie.200800590

Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

Alex M. Szpilman
, Jeffrey M. Manthorpe
, Erick M. Carreira

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

46 ציטוטים ‏(Scopus)

תקציר

(Chemical Presented) An indispensable OH group: The synthesis of 35-deoxy amphotericin B methyl ester was completed by using a novel method for the coupling of the mycosamine to the aglycone. The investigation of the antifungal activity and efflux-inducing ability of this compound provided data that underscore the relevance of the hydroxy group at C35 and supports the involvement of double-barrel ion channels.

שפה מקורית	אנגלית
עמודים (מ-עד)	4339-4342
מספר עמודים	4
כתב עת	Angewandte Chemie - International Edition
כרך	47
מספר גיליון	23
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1002/anie.200800590
סטטוס פרסום	פורסם - 26 מאי 2008
פורסם באופן חיצוני	כן

גישה למסמך

10.1002/anie.200800590

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

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title = "Synthesis and biological studies of 35-deoxy amphotericin B methyl ester",

abstract = "(Chemical Presented) An indispensable OH group: The synthesis of 35-deoxy amphotericin B methyl ester was completed by using a novel method for the coupling of the mycosamine to the aglycone. The investigation of the antifungal activity and efflux-inducing ability of this compound provided data that underscore the relevance of the hydroxy group at C35 and supports the involvement of double-barrel ion channels.",

keywords = "Amphotericin B, Antifungal agents, Mechanism of action, Natural products, Total synthesis",

author = "Szpilman, \{Alex M.\} and Manthorpe, \{Jeffrey M.\} and Carreira, \{Erick M.\}",

year = "2008",

month = may,

day = "26",

doi = "10.1002/anie.200800590",

language = "אנגלית",

volume = "47",

pages = "4339--4342",

journal = "Angewandte Chemie - International Edition",

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T1 - Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

AU - Szpilman, Alex M.

AU - Manthorpe, Jeffrey M.

AU - Carreira, Erick M.

PY - 2008/5/26

Y1 - 2008/5/26

N2 - (Chemical Presented) An indispensable OH group: The synthesis of 35-deoxy amphotericin B methyl ester was completed by using a novel method for the coupling of the mycosamine to the aglycone. The investigation of the antifungal activity and efflux-inducing ability of this compound provided data that underscore the relevance of the hydroxy group at C35 and supports the involvement of double-barrel ion channels.

AB - (Chemical Presented) An indispensable OH group: The synthesis of 35-deoxy amphotericin B methyl ester was completed by using a novel method for the coupling of the mycosamine to the aglycone. The investigation of the antifungal activity and efflux-inducing ability of this compound provided data that underscore the relevance of the hydroxy group at C35 and supports the involvement of double-barrel ion channels.

KW - Amphotericin B

KW - Antifungal agents

KW - Mechanism of action

KW - Natural products

KW - Total synthesis

UR - https://www.scopus.com/pages/publications/46749087921

U2 - 10.1002/anie.200800590

DO - 10.1002/anie.200800590

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C2 - 18442156

AN - SCOPUS:46749087921

SN - 1433-7851

VL - 47

SP - 4339

EP - 4342

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

Synthesis and biological studies of 35-deoxy amphotericin B methyl ester

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