Streptococcus pyogenes sortase mutants are highly susceptible to killing by host factors due to aberrant envelope physiology

Keyphrases

• Streptococcus Pyogenes (S. pyogenes) 100%
• Host Factors 100%
• Sortase A 100%
• LPXTG Motif 42%
• Virulence Factors 28%
• Sorting Signal 28%
• Highly Sensitive 14%
• Antibacterial Agents 14%
• Cellular Physiology 14%
• Gram-positive Bacteria 14%
• Small Molecule Inhibitors 14%
• Host Environment 14%
• Surface Proteins 14%
• Loss Function 14%
• Membrane Integrity 14%
• M Protein 14%
• Rapid Elimination 14%
• Cell Wall 14%
• Positively Charged Amino Acid 14%
• Normal Anatomy 14%
• Bacterial Physiology 14%
• Cellular Morphology 14%
• Septum 14%
• Cathelicidin 14%
• Unanticipated Effects 14%
• Surface Anchoring 14%
• Leader Sequence 14%
• Function Effect 14%

Immunology and Microbiology

• Streptococcus pyogenes 100%
• Host Factor 100%
• Sortase 100%
• Virulence Factor 28%
• Wild Type 14%
• Blood Plasma 14%
• Infectious Agent 14%
• Amino Terminal Sequence 14%
• Infectious Disease 14%
• Gram-Positive Bacteria 14%
• Cell Wall 14%
• Amino Acid 14%
• Bacterial Phenomena and Functions 14%
• Infection 14%
• Cathelicidin 14%

Biochemistry, Genetics and Molecular Biology

• Sortase 100%
• Streptococcus pyogenes 100%
• Virulence Factor 33%
• Wild Type 16%
• Infectious Agent 16%
• Amino Acids 16%
• N-Terminus 16%
• Small Molecule 16%
• Signal Peptide 16%
• Gram Positive Bacterium 16%
• Blood Plasma 16%
• Sortase A 16%
• Bacterial Phenomena and Functions 16%
• Cathelicidin 16%