SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman; Frank K. Huynh; Reuven Gil; Yair Glick; Yael Shahar; Noga Touitou; Liat Nahum; Matan Y. Avivi; Asael Roichman; Yariv Kanfi; Asaf A. Gertler; Tirza Doniger; Olga R. Ilkayeva; Ifat Abramovich; Orly Yaron; Batia Lerrer; Eyal Gottlieb; Robert A. Harris; Doron Gerber; Matthew D. Hirschey; Haim Y. Cohen

doi:10.1016/j.celrep.2019.11.067

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman
, Frank K. Huynh
, Reuven Gil
, Yair Glick
, Yael Shahar
, Noga Touitou
, Liat Nahum
, Matan Y. Avivi
, Asael Roichman
, Yariv Kanfi
, Asaf A. Gertler
, Tirza Doniger
, Olga R. Ilkayeva
, Ifat Abramovich
, Orly Yaron
, Batia Lerrer
, Eyal Gottlieb
, Robert A. Harris
, Doron Gerber
, Matthew D. Hirschey

Haim Y. Cohen

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

91 ציטוטים ‏(Scopus)

תקציר

How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

שפה מקורית	אנגלית
עמודים (מ-עד)	4127-4143.e8
כתב עת	Cell Reports
כרך	29
מספר גיליון	12
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1016/j.celrep.2019.11.067
סטטוס פרסום	פורסם - 17 דצמ׳ 2019
פורסם באופן חיצוני	כן

גישה למסמך

10.1016/j.celrep.2019.11.067

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., ... Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports, 29(12), 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

@article{2ee51ff8ff8d40ff96e784b510424ebe,

title = "SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα",

abstract = "How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.",

keywords = "PPARα, SIRT6, beta-oxidation, deacetylase, fasting, liver",

author = "Shoshana Naiman and Huynh, \{Frank K.\} and Reuven Gil and Yair Glick and Yael Shahar and Noga Touitou and Liat Nahum and Avivi, \{Matan Y.\} and Asael Roichman and Yariv Kanfi and Gertler, \{Asaf A.\} and Tirza Doniger and Ilkayeva, \{Olga R.\} and Ifat Abramovich and Orly Yaron and Batia Lerrer and Eyal Gottlieb and Harris, \{Robert A.\} and Doron Gerber and Hirschey, \{Matthew D.\} and Cohen, \{Haim Y.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = dec,

day = "17",

doi = "10.1016/j.celrep.2019.11.067",

language = "אנגלית",

volume = "29",

pages = "4127--4143.e8",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

number = "12",

}

Naiman, S, Huynh, FK, Gil, R, Glick, Y, Shahar, Y, Touitou, N, Nahum, L, Avivi, MY, Roichman, A, Kanfi, Y, Gertler, AA, Doniger, T, Ilkayeva, OR, Abramovich, I, Yaron, O, Lerrer, B, Gottlieb, E, Harris, RA, Gerber, D, Hirschey, MD & Cohen, HY 2019, 'SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα', Cell Reports, כרך 29, מס' 12, עמודים 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

TY - JOUR

T1 - SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

AU - Naiman, Shoshana

AU - Huynh, Frank K.

AU - Gil, Reuven

AU - Glick, Yair

AU - Shahar, Yael

AU - Touitou, Noga

AU - Nahum, Liat

AU - Avivi, Matan Y.

AU - Roichman, Asael

AU - Kanfi, Yariv

AU - Gertler, Asaf A.

AU - Doniger, Tirza

AU - Ilkayeva, Olga R.

AU - Abramovich, Ifat

AU - Yaron, Orly

AU - Lerrer, Batia

AU - Gottlieb, Eyal

AU - Harris, Robert A.

AU - Gerber, Doron

AU - Hirschey, Matthew D.

AU - Cohen, Haim Y.

PY - 2019/12/17

Y1 - 2019/12/17

N2 - How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

AB - How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

KW - PPARα

KW - SIRT6

KW - beta-oxidation

KW - deacetylase

KW - fasting

KW - liver

UR - https://www.scopus.com/pages/publications/85076344864

U2 - 10.1016/j.celrep.2019.11.067

DO - 10.1016/j.celrep.2019.11.067

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 31851938

AN - SCOPUS:85076344864

SN - 2211-1247

VL - 29

SP - 4127-4143.e8

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

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