TY - JOUR
T1 - Post-traumatic stress disorder
T2 - Facts and fiction
AU - Zohar, Joseph
AU - Juven-Wetzler, Alzbeta
AU - Myers, Vicki
AU - Fostick, Leah
PY - 2008/1
Y1 - 2008/1
N2 - PURPOSE OF REVIEW: This review provides an update on contemporary perspectives on post-traumatic stress disorder and challenges myths about the disorder and its treatment. Post-traumatic stress disorder has recently attracted public attention because of the impact of international terrorism, although the vast majority of post-traumatic stress disorder cases actually relate to civilian events such as car accidents, rape and violent robbery. This disorder requires deeper understanding and consensus among professionals. RECENT FINDINGS: Advances have been made in elucidating the neurobiology of this disorder, partly by using an animal model of post-traumatic stress disorder. Recent studies have focused on memory processes and the therapeutic role played by plasticity of the hypothalamic-pituitary-adrenal axis, and how this fits (or does not fit) in with the current therapeutic interventions. Guidelines have been established by various bodies in an attempt to streamline treatment options. SUMMARY: Understanding of post-traumatic stress disorder is incomplete. Future research should attempt to determine what treatments given during the 'window of opportunity' - the time from exposure until post-traumatic stress disorder develops - are effective. Care should be taken not to interfere with spontaneous recovery.
AB - PURPOSE OF REVIEW: This review provides an update on contemporary perspectives on post-traumatic stress disorder and challenges myths about the disorder and its treatment. Post-traumatic stress disorder has recently attracted public attention because of the impact of international terrorism, although the vast majority of post-traumatic stress disorder cases actually relate to civilian events such as car accidents, rape and violent robbery. This disorder requires deeper understanding and consensus among professionals. RECENT FINDINGS: Advances have been made in elucidating the neurobiology of this disorder, partly by using an animal model of post-traumatic stress disorder. Recent studies have focused on memory processes and the therapeutic role played by plasticity of the hypothalamic-pituitary-adrenal axis, and how this fits (or does not fit) in with the current therapeutic interventions. Guidelines have been established by various bodies in an attempt to streamline treatment options. SUMMARY: Understanding of post-traumatic stress disorder is incomplete. Future research should attempt to determine what treatments given during the 'window of opportunity' - the time from exposure until post-traumatic stress disorder develops - are effective. Care should be taken not to interfere with spontaneous recovery.
KW - Animal model
KW - Benzodiazepines
KW - Hypothalamic-pituitary-adrenal axis
KW - Post-traumatic stress disorder
UR - http://www.scopus.com/inward/record.url?scp=40349105878&partnerID=8YFLogxK
U2 - 10.1097/YCO.0b013e3282f269ee
DO - 10.1097/YCO.0b013e3282f269ee
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C2 - 18281844
AN - SCOPUS:40349105878
SN - 0951-7367
VL - 21
SP - 74
EP - 77
JO - Current Opinion in Psychiatry
JF - Current Opinion in Psychiatry
IS - 1
ER -