TY - JOUR
T1 - Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel
AU - Navon-Venezia, Shiri
AU - Chmelnitsky, Inna
AU - Leavitt, Azita
AU - Schwaber, Mitchell J.
AU - Schwartz, David
AU - Carmeli, Yehuda
PY - 2006/9
Y1 - 2006/9
N2 - Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.
AB - Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.
UR - http://www.scopus.com/inward/record.url?scp=33748698691&partnerID=8YFLogxK
U2 - 10.1128/AAC.00438-06
DO - 10.1128/AAC.00438-06
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C2 - 16940107
AN - SCOPUS:33748698691
SN - 0066-4804
VL - 50
SP - 3098
EP - 3101
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
ER -