Pharmacological and alimentary alteration of the gastric barrier

Doron Boltin, Yaron Niv

פרסום מחקרי: פרסום בכתב עתסקירהביקורת עמיתים

27 ציטוטים ‏(Scopus)

תקציר

The gastric barrier contains several lines of defence which protect the epithelium from harmful microbes and toxins. Pre-mucosal defence mechanisms include secreted acid (HCl 0.1 mmol/L) and pepsin, which are capable of denaturing tissue. A tightly adherent mucous layer provides the next line of defence, and physically separates any potentially hazardous substance in the lumen from the mucosal surface. Apical secretion of HCO3- maintains a nonacidic microenvironment at the mucosal surface. Membranebound phospholipids repel soluble toxins, and sulphydryls scavenge reactive oxygen species. However, when noxious agents overwhelm these mechanisms, the epithelium is damaged. Herein, we discuss the pathological and physiological basis for several disease states which are associated with a breakdown in one or more components of the gastric barrier, including: Helicobacter pylori-associated gastritis, atrophic gastritis, stress-related mucosal disease, age-related gastropathy and portal hypertensive gastropathy. The effect of non-steroidal anti-inflammatory drugs and proton pump inhibitors on the gastric mucosa, is explored. Finally, we outline the alterations in mucosal defence caused by alcohol, caffeine, minerals and vitamins.

שפה מקוריתאנגלית
עמודים (מ-עד)981-994
מספר עמודים14
כתב עתBest Practice and Research: Clinical Gastroenterology
כרך28
מספר גיליון6
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 2014
פורסם באופן חיצוניכן

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