תקציר
Few cases of pamidronate (bis-phosphonate class of drugs) nephrotoxicity in humans have been previously reported in the literature. In 7 patients, the pamidronate-related nephrotoxicity was attributed to focal collapsing glomerulosclerosis [Markowitz et al. 2001], and in 1 patient was related to tubulo-interstitial inflammatory nephritis [Van Doorn et al. 2001]. We report herein on a 65-year-old Caucasian female patient who presented with acute chronic renal failure due to pamidronate-induced toxic proximal tubular necrosis without immunologic or inflammatory tubulo-interstitial involvement. The acute pattern of renal failure resolved following cessation of pamidronate administration in this patient for osteoporosis; the patient also had a monoclonal gammopathy of unspecific origin (MGUS).
שפה מקורית | אנגלית |
---|---|
עמודים (מ-עד) | 63-67 |
מספר עמודים | 5 |
כתב עת | Clinical Nephrology |
כרך | 61 |
מספר גיליון | 1 |
מזהי עצם דיגיטלי (DOIs) | |
סטטוס פרסום | פורסם - ינו׳ 2004 |
פורסם באופן חיצוני | כן |