One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

Gary Gellerman; Vladimir Gaisin; Tamara Brider

doi:10.1016/j.tetlet.2009.12.020

One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and S_NAr reaction

Gary Gellerman
, Vladimir Gaisin
, Tamara Brider

מדעי הכימיה

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

14 ציטוטים ‏(Scopus)

תקציר

A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and S_NAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

שפה מקורית	אנגלית
עמודים (מ-עד)	836-839
מספר עמודים	4
כתב עת	Tetrahedron Letters
כרך	51
מספר גיליון	5
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1016/j.tetlet.2009.12.020
סטטוס פרסום	פורסם - 3 פבר׳ 2010

גישה למסמך

10.1016/j.tetlet.2009.12.020

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

@article{435306938548495e82a13cc5674390f8,

title = "One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction",

abstract = "A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.",

keywords = "9-Aminoacridine, Nucleophilic substitution, One-pot synthesis, Reductive alkylation",

author = "Gary Gellerman and Vladimir Gaisin and Tamara Brider",

year = "2010",

month = feb,

day = "3",

doi = "10.1016/j.tetlet.2009.12.020",

language = "אנגלית",

volume = "51",

pages = "836--839",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "5",

}

TY - JOUR

T1 - One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

AU - Gellerman, Gary

AU - Gaisin, Vladimir

AU - Brider, Tamara

PY - 2010/2/3

Y1 - 2010/2/3

N2 - A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

AB - A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

KW - 9-Aminoacridine

KW - Nucleophilic substitution

KW - One-pot synthesis

KW - Reductive alkylation

UR - https://www.scopus.com/pages/publications/73049084566

U2 - 10.1016/j.tetlet.2009.12.020

DO - 10.1016/j.tetlet.2009.12.020

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:73049084566

SN - 0040-4039

VL - 51

SP - 836

EP - 839

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5