TY - JOUR
T1 - Neonatal benzodiazepines exposure during breastfeeding
AU - Kelly, Lauren E.
AU - Poon, Shirley
AU - Madadi, Parvaz
AU - Koren, Gideon
N1 - Funding Information:
Supported by the Ivey Chair in Molecular Toxicology at the University of Western Ontario. L.K. and P.M. are funded by the Canadian Pharmacogenomics Network for Drug Safety and the Canadian Institutes of Health Research . The authors declare no conflicts of interest.
PY - 2012/9
Y1 - 2012/9
N2 - Objective: To assess central nervous system depression and other adverse effects in infants exposed to benzodiazepines through breast milk. Study design: A prospectively recruited, retrospectively assessed cohort study of mothers who contacted the Motherisk program regarding the safety of benzodiazepines and were invited to participate in a follow-up program regarding the effects of these medications on their infants during lactation. Results: A total of 124 consenting women participated. Adverse outcomes, specifically sedation, was identified in only 1.6% (2 of 124) of infants and was not associated with benzodiazepine dose, number of hours breastfed, or any demographic trait. Mothers reporting adverse outcomes in themselves (26% [32 of 124]) were more likely to be taking concomitantly a greater number of central nervous system depressants. Conclusions: This study supports the continued recommendation to initiate breastfeeding while taking benzodiazepines postpartum.
AB - Objective: To assess central nervous system depression and other adverse effects in infants exposed to benzodiazepines through breast milk. Study design: A prospectively recruited, retrospectively assessed cohort study of mothers who contacted the Motherisk program regarding the safety of benzodiazepines and were invited to participate in a follow-up program regarding the effects of these medications on their infants during lactation. Results: A total of 124 consenting women participated. Adverse outcomes, specifically sedation, was identified in only 1.6% (2 of 124) of infants and was not associated with benzodiazepine dose, number of hours breastfed, or any demographic trait. Mothers reporting adverse outcomes in themselves (26% [32 of 124]) were more likely to be taking concomitantly a greater number of central nervous system depressants. Conclusions: This study supports the continued recommendation to initiate breastfeeding while taking benzodiazepines postpartum.
UR - https://www.scopus.com/pages/publications/84865323996
U2 - 10.1016/j.jpeds.2012.03.003
DO - 10.1016/j.jpeds.2012.03.003
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C2 - 22504099
AN - SCOPUS:84865323996
SN - 0022-3476
VL - 161
SP - 448
EP - 451
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -