TY - JOUR
T1 - Long-term Neurodevelopment of Children Exposed to Maternal Nausea and Vomiting of Pregnancy and Diclectin
AU - Nulman, Irena
AU - Rovet, Joanne
AU - Barrera, Maru
AU - Knittel-Keren, Dafna
AU - Feldman, Brian M.
AU - Koren, Gideon
N1 - Funding Information:
Supported by Duchesnay (Laval, Quebec). G.K. has served as a paid consultant for Duchesnay. G.K. and I.N. hold a CIHR Collaborative grant with Duchesnay.
PY - 2009/7
Y1 - 2009/7
N2 - Objective: To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment. Study design: An observational cohort study of mother-child pairs ascertained via a pregnancy call-in center was conducted. Three groups of children were studied: 45 with NVP and diclectin, 47 with NVP no diclectin, and 29 with no NVP. Phone calls to mothers during pregnancy and 6 to 9 months after childbirth yielded information on pregnancy, birth, and early child development. Children aged 3 to 7 years received a comprehensive set of psychological tests. Mothers were assessed for IQ and socioeconomic status. Results: All children scored in the normal range for IQ, with the NVP-exposed group scoring higher than the non-exposed group on Performance IQ (P < .02), NEPSY Verbal Fluency (P < .003) and Phonological Processing (P < .004), and McCarthy Numerical Memory (P < .004). Predictors of enhanced results were NVP severity and maternal IQ. Conclusions: NVP has an enhancing effect on later child outcome. Diclectin does not appear to adversely affect fetal brain development and can be used to control NVP when clinically indicated.
AB - Objective: To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment. Study design: An observational cohort study of mother-child pairs ascertained via a pregnancy call-in center was conducted. Three groups of children were studied: 45 with NVP and diclectin, 47 with NVP no diclectin, and 29 with no NVP. Phone calls to mothers during pregnancy and 6 to 9 months after childbirth yielded information on pregnancy, birth, and early child development. Children aged 3 to 7 years received a comprehensive set of psychological tests. Mothers were assessed for IQ and socioeconomic status. Results: All children scored in the normal range for IQ, with the NVP-exposed group scoring higher than the non-exposed group on Performance IQ (P < .02), NEPSY Verbal Fluency (P < .003) and Phonological Processing (P < .004), and McCarthy Numerical Memory (P < .004). Predictors of enhanced results were NVP severity and maternal IQ. Conclusions: NVP has an enhancing effect on later child outcome. Diclectin does not appear to adversely affect fetal brain development and can be used to control NVP when clinically indicated.
UR - http://www.scopus.com/inward/record.url?scp=67649763432&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2009.02.005
DO - 10.1016/j.jpeds.2009.02.005
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C2 - 19394042
AN - SCOPUS:67649763432
SN - 0022-3476
VL - 155
SP - 45-50.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 1
ER -