TY - JOUR
T1 - Lack of association between severity of ADHD symptoms and salivary oxytocin levels
AU - Boyle, Dennis
AU - Levi-Shachar, Orit
AU - Gvirts, Hila Z.
AU - Zagoory-Sharon, Orna
AU - Feldman, Ruth
AU - Bloch, Yuval
AU - Nitzan, Uriel
AU - Maoz, Hagai
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/9
Y1 - 2021/9
N2 - Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 ± 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.
AB - Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 ± 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.
KW - Attention deficit hyperactivity disorder (ADHD)
KW - Oxytocin
KW - Social cognition
UR - https://www.scopus.com/pages/publications/85107147948
U2 - 10.1016/j.psyneuen.2021.105293
DO - 10.1016/j.psyneuen.2021.105293
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C2 - 34090136
AN - SCOPUS:85107147948
SN - 0306-4530
VL - 131
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
M1 - 105293
ER -