Laboratory evaluation of different agar media for isolation of carbapenem-resistant Acinetobacter spp

J. Moran-Gilad; A. Adler; D. Schwartz; S. Navon-Venezia; Y. Carmeli

doi:10.1007/s10096-014-2159-y

Laboratory evaluation of different agar media for isolation of carbapenem-resistant Acinetobacter spp

J. Moran-Gilad
, A. Adler
, D. Schwartz
, S. Navon-Venezia
, Y. Carmeli

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

11 ציטוטים ‏(Scopus)

תקציר

The optimal method for surveillance of carbapenem-resistant Acinetobacter spp. (CRAB) is unknown. A collection of CRAB strains (n = 42), carbapenem-susceptible strains (CSAB), and non-Acinetobacter strains (n = 18) was used to evaluate six laboratory surveillance methods: MacConkey (MAC), MAC + 1 μg/ml imipenem (MAC-IPM), minimal salts agar + 1 % acetate (MSA), MSA with IPM disk (MSA-IPM), CHROMagarKPC, and CHROMagar Acinetobacter with CR102 (CHROMAcineto). CHROMAcineto was 100 % sensitive and specific. CHROMagarKPC and MAC-IPM were highly sensitive (>95 %), but their specificity was substantially hampered by the breakthrough growth of CSAB. MSA was unsuitable for CRAB detection. CHROMAcineto is a promising medium for CRAB detection and warrants further clinical evaluation.

שפה מקורית	אנגלית
עמודים (מ-עד)	1909-1913
מספר עמודים	5
כתב עת	European Journal of Clinical Microbiology and Infectious Diseases
כרך	33
מספר גיליון	11
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1007/s10096-014-2159-y
סטטוס פרסום	פורסם - 19 אוק׳ 2014

גישה למסמך

10.1007/s10096-014-2159-y

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

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title = "Laboratory evaluation of different agar media for isolation of carbapenem-resistant Acinetobacter spp",

abstract = "The optimal method for surveillance of carbapenem-resistant Acinetobacter spp. (CRAB) is unknown. A collection of CRAB strains (n = 42), carbapenem-susceptible strains (CSAB), and non-Acinetobacter strains (n = 18) was used to evaluate six laboratory surveillance methods: MacConkey (MAC), MAC + 1 μg/ml imipenem (MAC-IPM), minimal salts agar + 1 \% acetate (MSA), MSA with IPM disk (MSA-IPM), CHROMagarKPC, and CHROMagar Acinetobacter with CR102 (CHROMAcineto). CHROMAcineto was 100 \% sensitive and specific. CHROMagarKPC and MAC-IPM were highly sensitive (>95 \%), but their specificity was substantially hampered by the breakthrough growth of CSAB. MSA was unsuitable for CRAB detection. CHROMAcineto is a promising medium for CRAB detection and warrants further clinical evaluation.",

author = "J. Moran-Gilad and A. Adler and D. Schwartz and S. Navon-Venezia and Y. Carmeli",

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AU - Adler, A.

AU - Schwartz, D.

AU - Navon-Venezia, S.

AU - Carmeli, Y.

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N2 - The optimal method for surveillance of carbapenem-resistant Acinetobacter spp. (CRAB) is unknown. A collection of CRAB strains (n = 42), carbapenem-susceptible strains (CSAB), and non-Acinetobacter strains (n = 18) was used to evaluate six laboratory surveillance methods: MacConkey (MAC), MAC + 1 μg/ml imipenem (MAC-IPM), minimal salts agar + 1 % acetate (MSA), MSA with IPM disk (MSA-IPM), CHROMagarKPC, and CHROMagar Acinetobacter with CR102 (CHROMAcineto). CHROMAcineto was 100 % sensitive and specific. CHROMagarKPC and MAC-IPM were highly sensitive (>95 %), but their specificity was substantially hampered by the breakthrough growth of CSAB. MSA was unsuitable for CRAB detection. CHROMAcineto is a promising medium for CRAB detection and warrants further clinical evaluation.

AB - The optimal method for surveillance of carbapenem-resistant Acinetobacter spp. (CRAB) is unknown. A collection of CRAB strains (n = 42), carbapenem-susceptible strains (CSAB), and non-Acinetobacter strains (n = 18) was used to evaluate six laboratory surveillance methods: MacConkey (MAC), MAC + 1 μg/ml imipenem (MAC-IPM), minimal salts agar + 1 % acetate (MSA), MSA with IPM disk (MSA-IPM), CHROMagarKPC, and CHROMagar Acinetobacter with CR102 (CHROMAcineto). CHROMAcineto was 100 % sensitive and specific. CHROMagarKPC and MAC-IPM were highly sensitive (>95 %), but their specificity was substantially hampered by the breakthrough growth of CSAB. MSA was unsuitable for CRAB detection. CHROMAcineto is a promising medium for CRAB detection and warrants further clinical evaluation.

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Laboratory evaluation of different agar media for isolation of carbapenem-resistant Acinetobacter spp

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