תקציר
Upon permanent stresses and in various diseases, small protein aggregates may accumulate in cells and cause toxicity. A recently discovered protective system transports these aggregates to the centrosome location via microtubules, to form a large agglomerate of aggregates called the aggresome. Here, we describe a newly developed method for isolating aggresomes. This principle can also be used for purification of other large structures and even organelles.
שפה מקורית | אנגלית |
---|---|
עמודים (מ-עד) | 3.38.1-3.38.9 |
כתב עת | Current Protocols in Cell Biology |
מספר גיליון | SUPP.48 |
מזהי עצם דיגיטלי (DOIs) | |
סטטוס פרסום | פורסם - 2010 |
פורסם באופן חיצוני | כן |