TY - JOUR
T1 - Involvement of prostaglandins in an animal model of Shigella-related seizures
AU - Yuhas, Yael
AU - Weizman, Abraham
AU - Vanichkin, Alexey
AU - Ashkenazi, Shai
PY - 2005/11
Y1 - 2005/11
N2 - We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.
AB - We investigated whether prostaglandins (PGs), proinflammatory mediators implicated in excitatory activity, are involved in Shigella-related seizures. Pretreatment with S. dysenteriae sonicate (2LD50) enhanced mice response to pentylenetetrazole-induced seizures, without increase of brain concentrations of PGE2, PGD2 or PGF2α. Preinjection of NS-398, an inhibitor of cyclooxygenase-2, before treatment with Shigella sonicate, had no effect on seizures. The anticonvulsive PGD2 increased after injection of 8 LD50 of Shigella sonicate, which did not enhance seizures (32 pg/mg vs 26 pg/ml, p = 0.0063). The findings indicate that PGs are not involved in the enhanced seizure response after exposure to Shigella. However, induction of PGD2 may play an inhibitory role.
KW - Animal model
KW - Prostaglandins
KW - Seizures
KW - Shigella
UR - http://www.scopus.com/inward/record.url?scp=25844494539&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2005.06.029
DO - 10.1016/j.jneuroim.2005.06.029
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C2 - 16139898
AN - SCOPUS:25844494539
SN - 0165-5728
VL - 168
SP - 34
EP - 39
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -