Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky; Shahar Rotem; Dmitry Bourdetsky; Shiri Navon-Venezia; Yehuda Carmeli; Amram Mor

doi:10.1038/nbt1309

Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky
, Shahar Rotem
, Dmitry Bourdetsky
, Shiri Navon-Venezia
, Yehuda Carmeli
, Amram Mor

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

246 ציטוטים ‏(Scopus)

תקציר

We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

שפה מקורית	אנגלית
עמודים (מ-עד)	657-659
מספר עמודים	3
כתב עת	Nature Biotechnology
כרך	25
מספר גיליון	6
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1038/nbt1309
סטטוס פרסום	פורסם - יוני 2007
פורסם באופן חיצוני	כן

גישה למסמך

10.1038/nbt1309

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

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title = "Improved antimicrobial peptides based on acyl-lysine oligomers",

abstract = "We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.",

author = "Radzishevsky, \{Inna S.\} and Shahar Rotem and Dmitry Bourdetsky and Shiri Navon-Venezia and Yehuda Carmeli and Amram Mor",

note = "Funding Information: This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).",

year = "2007",

month = jun,

doi = "10.1038/nbt1309",

language = "אנגלית",

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T1 - Improved antimicrobial peptides based on acyl-lysine oligomers

AU - Radzishevsky, Inna S.

AU - Rotem, Shahar

AU - Bourdetsky, Dmitry

AU - Navon-Venezia, Shiri

AU - Carmeli, Yehuda

AU - Mor, Amram

N1 - Funding Information: This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).

PY - 2007/6

Y1 - 2007/6

N2 - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

AB - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

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VL - 25

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JO - Nature Biotechnology

JF - Nature Biotechnology

IS - 6

ER -

Improved antimicrobial peptides based on acyl-lysine oligomers

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