Healing of rachitic lesions in chicks by 24R,25‐dihydroxycholecalciferol administered locally into bone

Cobi Lidor, Isaac Atkin, Asher Ornoy, Samuel Dekel, Samuel Edelstein

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

39 ציטוטים ‏(Scopus)

תקציר

In an attempt to further define the nature of the active metabolite in bone formation, a series of experiments were conducted whereby vitamin D metabolites were administered locally in vivo into the proximal epiphyseal growth plate of the tibiae of rachitic chicks. Local administration of 3 μg of 24,25(OH)2D3 in vivo to D‐deficient chicks resulted in disappearance of the rachitic lesions in the same leg. Administration of 1 μg 1,25(OH)2D3 in a similar manner failed to show any sign of healing. Injection of 5 μg 25(OH)D3 was followed by recovery from rickets in both the injected right leg and in the vehicle‐injected left tibia, although the recovery was more pronounced in the injected leg. Lower doses of 0.3 or 1 μg 24,25(OH)2D3 failed to reverse the rachitic lesions and induced only minimal recovery. These findings suggest that 24,25(OH)2D3 at the higher doses has a direct local effect on cartilage and bone, while 1,25(OH)2D3 has no such effect in chicks. 25(OH)D3 is probably absorbed from the epiphyses into the blood stream and converted into the active metabolites, which were indeed detected in the blood to exert its systemic effects.

שפה מקוריתאנגלית
עמודים (מ-עד)91-98
מספר עמודים8
כתב עתJournal of Bone and Mineral Research
כרך2
מספר גיליון2
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - אפר׳ 1987
פורסם באופן חיצוניכן

טביעת אצבע

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