Hairy cell leukemia with an autoimmune syndrome, paraproteinemia, and cryoglobulinemia

We have described an 82-year-old man with HCL who had autoimmune manifestations, paraproteinemia, and cryoglobulinemia. Chemotherapy resulted in a dramatic response, with a decrease in the tumor mass, a reduction in the clinical and serologic features of the autoimmune syndrome, and disappearance of the cryoglobulin, but without a significant change in the serum level of paraprotein.