Genetic and environmental influences on IL-6 and TNF-α plasma levels in apparently healthy general population

Ia Pantsulaia, Svetlana Trofimov, Eugene Kobyliansky, Gregory Livshits

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

55 ציטוטים ‏(Scopus)

תקציר

Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma levels of IL-6 and TNF-α in 91 nuclear and more complex pedigrees of Caucasian ethnic origin (N=401 individuals). The maximum likelihood based variance decomposition analysis showed significant positive correlation between circulating IL-6 and age in both genders. The magnitude of these correlations in our sample ranged from 0.22 in females to 0.28 in males (P<0.001). Significant association between TNF-α and IL-6 (r=0.28, r=0.43; P<0.001; respectively for men and women) was also observed. Likelihood ratio test clearly revealed that additive genetic effect for TNF-α was highly significant (P<0.001), and accounted over 80% of its variation, adjusted for IL-6 levels and age. In contrast, heritability estimate for IL-6 adjusted for age and TNF-α, revealed small contribution of genetic factors (24.1 ± 10.2%). The bivariate variance component analysis demonstrated that significant relationship between IL-6 and TNF-α was due to shared environment only (rE=0.760 ± 0.140). As evinced from our complex segregation analysis the nature of the genetic determinant of each of these two cytokines is quite complex and it is probably oligogenic.

שפה מקוריתאנגלית
עמודים (מ-עד)138-146
מספר עמודים9
כתב עתCytokine
כרך19
מספר גיליון3
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 2002
פורסם באופן חיצוניכן

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