TY - JOUR
T1 - Favorable pregnancy outcome following Trastuzumab (Herceptin®) use during pregnancy-Case report and updated literature review
AU - Shrim, Alon
AU - Garcia-Bournissen, Facundo
AU - Maxwell, Cynthia
AU - Farine, Dan
AU - Koren, Gideon
N1 - Funding Information:
Supported in part by the research Leadership for Better Pharmacotherapy during pregnancy and Lactation (Hospital for Sick Children) and the Ivey chair in molecular toxicology, Department of Medicine, University of western Ontario. AS was supported by a grant from the Hospital for Sick Children's research training centre. The Motherisk-NVP line is supported in part by Duchesnay Inc., Laval, Canada.
PY - 2007/6
Y1 - 2007/6
N2 - Background: Trastuzumab (Herceptin®) is a monoclonal antibody used for the treatment of breast cancer. Experience with use of this agent during pregnancy, and its possible effects on the fetus, is limited. Case: We present a case of a patient with breast cancer who was treated with trastuzumab during the first 24 weeks of pregnancy. This treatment was associated with reversible maternal heart failure, which resolved slowly after the drug was discontinued, but with no adverse fetal effects and a normal infant examination at the age of 2 months. Updated literature review is discussed.
AB - Background: Trastuzumab (Herceptin®) is a monoclonal antibody used for the treatment of breast cancer. Experience with use of this agent during pregnancy, and its possible effects on the fetus, is limited. Case: We present a case of a patient with breast cancer who was treated with trastuzumab during the first 24 weeks of pregnancy. This treatment was associated with reversible maternal heart failure, which resolved slowly after the drug was discontinued, but with no adverse fetal effects and a normal infant examination at the age of 2 months. Updated literature review is discussed.
KW - Breast cancer
KW - Cancer treatment in pregnancy
KW - Chemotherapy
KW - Pregnancy
KW - Teratology
UR - https://www.scopus.com/pages/publications/34248587204
U2 - 10.1016/j.reprotox.2007.02.003
DO - 10.1016/j.reprotox.2007.02.003
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C2 - 17399946
AN - SCOPUS:34248587204
SN - 0890-6238
VL - 23
SP - 611
EP - 613
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 4
ER -