Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage

Daniel M. Weinberger, Ron Dagan, Noga Givon-Lavi, Gili Regev-Yochay, Richard Malley, Marc Lipsitch

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

106 ציטוטים ‏(Scopus)

תקציר

Nasopharyngeal carriage of Streptococcus pneumoniae is required for transmission of the bacteria and for invasive disease. There have been conflicting reports as to whether protection against carriage is serotype specific and which immune mechanisms drive carriage. Analyzing longitudinal carriage data from Israeli toddlers in day care, we found a lower risk of colonization with types 6A, 14, and 23F after previous exposure to the homologous type. Nonsignificant trends suggesting possible protection derived from prior exposure were found for types 19A and 23A. Furthermore, we found that, for types 14 and 23F, this specific protection correlated with increased serotype-specific antibody concentration. We found no evidence of specific protection for type 6B, group 15, or type 19F. Our findings imply that at least some serotypes generate anti-capsular antibodies that can reduce the risk of carriage in unimmunized toddlers.

שפה מקוריתאנגלית
עמודים (מ-עד)1511-1518
מספר עמודים8
כתב עתJournal of Infectious Diseases
כרך197
מספר גיליון11
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 יוני 2008
פורסם באופן חיצוניכן

טביעת אצבע

להלן מוצגים תחומי המחקר של הפרסום 'Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage'. יחד הם יוצרים טביעת אצבע ייחודית.

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