TY - JOUR
T1 - Effect of hypothermia on the pharmacokinetics of ethanol in piglets
AU - Koren, Gideon
AU - Barker, Charmain
AU - Bohn, Desmond
AU - Kent, Geraldine
AU - McGuigan, Michael
AU - Biggar, Douglas
N1 - Funding Information:
Gideon Koren, MD *ll Charmain Barker, BSctll Desmond Bohn, MD :~ll Geraldine Kent, DVM§I I Michael McGuigan, MD, CM *11 Douglas Biggar, MDtll Toronto, Ontario, Canada From the Divisions of Clinical Pharmacology and Toxicology,* Infectious Diseases,t Intensive Care,:~ and Surgical Research,§ Department of Pediatrics and the Research Institute, The Hospital for Sick Children; Departments of Pediatrics and Pharmacology, University of Toronto;I I and the Ontario Ministry of Health, Toronto, Ontario, Canada.
PY - 1989/2
Y1 - 1989/2
N2 - The effect of hypothermia (29 C) on the pharmacokinetics of ethanol was studied in eight piglets serving as their own normothermic controls. Ten milliliters of 12% ethanol per kilogram were infused over 30 minutes, and serum ethanol concentrations were measured for seven hours. Ethanol concentration data were fitted to one-compartment open model assuming Michaelis Menten elimination kinetics. During hypothermia, ethanol concentrations were consistently higher than during normothermia. This observation could be explained by both a significantly smaller distribution volume of ethanol during hypothermia (0.71 ± 0.03 L/kg at 29 C and 0.84 ± 0.05 L/kg at 37 C, P < .02) and a significantly slower maximum velocity of metabolism of ethanol (Vm) during hypothermia (1.12 ± 0.11 mg/kg·min vs 1.83 ± 0.21 mg/kg·min, P < .01). Our study indicates that during hypothermia, ethanol stays significantly longer in the circulation in piglets. Potentially, this may contribute to a more profound effect from the ethanol.
AB - The effect of hypothermia (29 C) on the pharmacokinetics of ethanol was studied in eight piglets serving as their own normothermic controls. Ten milliliters of 12% ethanol per kilogram were infused over 30 minutes, and serum ethanol concentrations were measured for seven hours. Ethanol concentration data were fitted to one-compartment open model assuming Michaelis Menten elimination kinetics. During hypothermia, ethanol concentrations were consistently higher than during normothermia. This observation could be explained by both a significantly smaller distribution volume of ethanol during hypothermia (0.71 ± 0.03 L/kg at 29 C and 0.84 ± 0.05 L/kg at 37 C, P < .02) and a significantly slower maximum velocity of metabolism of ethanol (Vm) during hypothermia (1.12 ± 0.11 mg/kg·min vs 1.83 ± 0.21 mg/kg·min, P < .01). Our study indicates that during hypothermia, ethanol stays significantly longer in the circulation in piglets. Potentially, this may contribute to a more profound effect from the ethanol.
KW - ethanol, effect of hypothermia
KW - hypothermia, ethanol
UR - https://www.scopus.com/pages/publications/0024537206
U2 - 10.1016/S0196-0644(89)80097-6
DO - 10.1016/S0196-0644(89)80097-6
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C2 - 2916773
AN - SCOPUS:0024537206
SN - 0196-0644
VL - 18
SP - 118
EP - 121
JO - Annals of Emergency Medicine
JF - Annals of Emergency Medicine
IS - 2
ER -