Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami; G. Rahav; H. Elinav; I. Kassis; I. Shalit; T. Gottesman; O. Megged; M. Weinberger; P. Ciobotaro; P. Shitrit; G. Weber; A. Paz; D. Miron; I. Oren; J. Bishara; C. Block; N. Keller; D. P. Kontoyiannis; M. Giladi

doi:10.1111/1469-0691.12004

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami, G. Rahav, H. Elinav, I. Kassis, I. Shalit, T. Gottesman, O. Megged, M. Weinberger, P. Ciobotaro, P. Shitrit, G. Weber, A. Paz, D. Miron, I. Oren, J. Bishara, C. Block, N. Keller, D. P. Kontoyiannis, M. Giladi

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

19 ציטוטים ‏(Scopus)

תקציר

The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

שפה מקורית	אנגלית
עמודים (מ-עד)	752-756
מספר עמודים	5
כתב עת	Clinical Microbiology and Infection
כרך	19
מספר גיליון	8
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1111/1469-0691.12004
סטטוס פרסום	פורסם - אוג׳ 2013
פורסם באופן חיצוני	כן

גישה למסמך

10.1111/1469-0691.12004

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

Ben-Ami, R., Rahav, G., Elinav, H., Kassis, I., Shalit, I., Gottesman, T., Megged, O., Weinberger, M., Ciobotaro, P., Shitrit, P., Weber, G., Paz, A., Miron, D., Oren, I., Bishara, J., Block, C., Keller, N., Kontoyiannis, D. P., & Giladi, M. (2013). Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel. Clinical Microbiology and Infection, 19(8), 752-756. https://doi.org/10.1111/1469-0691.12004

@article{144a9c3f0bb546e0899874d508fada8a,

title = "Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel",

abstract = "The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.",

keywords = "Candidaemia, Drug resistance, Epidemiology, Fluconazole",

author = "R. Ben-Ami and G. Rahav and H. Elinav and I. Kassis and I. Shalit and T. Gottesman and O. Megged and M. Weinberger and P. Ciobotaro and P. Shitrit and G. Weber and A. Paz and D. Miron and I. Oren and J. Bishara and C. Block and N. Keller and Kontoyiannis, {D. P.} and M. Giladi",

note = "Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases. ",

year = "2013",

month = aug,

doi = "10.1111/1469-0691.12004",

language = "אנגלית",

volume = "19",

pages = "752--756",

journal = "Clinical Microbiology and Infection",

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number = "8",

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Ben-Ami, R, Rahav, G, Elinav, H, Kassis, I, Shalit, I, Gottesman, T, Megged, O, Weinberger, M, Ciobotaro, P, Shitrit, P, Weber, G, Paz, A, Miron, D, Oren, I, Bishara, J, Block, C, Keller, N, Kontoyiannis, DP & Giladi, M 2013, 'Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel', Clinical Microbiology and Infection, כרך 19, מס' 8, עמודים 752-756. https://doi.org/10.1111/1469-0691.12004

TY - JOUR

T1 - Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

AU - Ben-Ami, R.

AU - Rahav, G.

AU - Elinav, H.

AU - Kassis, I.

AU - Shalit, I.

AU - Gottesman, T.

AU - Megged, O.

AU - Weinberger, M.

AU - Ciobotaro, P.

AU - Shitrit, P.

AU - Weber, G.

AU - Paz, A.

AU - Miron, D.

AU - Oren, I.

AU - Bishara, J.

AU - Block, C.

AU - Keller, N.

AU - Kontoyiannis, D. P.

AU - Giladi, M.

N1 - Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases.

PY - 2013/8

Y1 - 2013/8

N2 - The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

AB - The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

KW - Candidaemia

KW - Drug resistance

KW - Epidemiology

KW - Fluconazole

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SN - 1198-743X

VL - 19

SP - 752

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JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 8

ER -

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

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