Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma

Keyphrases

• Alkylator 25%
• Amide Bond Formation 25%
• Amonafide 100%
• Anticancer Drugs 50%
• Binder 25%
• Cancer Cell Lines 25%
• Cancer Cells 25%
• Chemotherapeutic Strategies 25%
• Chlorambucil 100%
• Covalent Coupling 25%
• DNA Interstrand Crosslinks 25%
• Enhanced Cytotoxicity 25%
• Growth Maintenance 25%
• Guanine 25%
• Human Metastatic Melanoma 100%
• In Silico Docking 25%
• Intrinsic Mechanism 25%
• Molecular chimerism 100%
• Mustard 25%
• Overall Survival 25%
• Small Molecules 25%
• Synthetic Strategies 25%
• Topoisomerase II 25%
• Topoisomerase II Inhibition 25%
• Topoisomerase Inhibitors 25%
• Tumor Growth 25%
• Xenograft Model 50%

Medicine and Dentistry

• Amonafide 100%
• Anticarcinogen 25%
• Body Weight 25%
• Cancer Cell 25%
• Cancer Cell Line 25%
• Carboxamide 25%
• Chemotherapy 50%
• Chlorambucil 100%
• Cytotoxicity 25%
• DNA Cross Linking 25%
• DNA Topoisomerase (ATP Hydrolysing) 50%
• Guanine 25%
• Gyrase Inhibitor 25%
• In Silico 25%
• Malignant Neoplasm 25%
• Metastatic Melanoma 100%
• Overall Survival 25%
• Tumor Progression 25%
• Xenograft 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Amonafide 100%
• Anticarcinogen 25%
• Carboxamide 25%
• Chlorambucil 100%
• Cytotoxicity 25%
• DNA Topoisomerase (ATP Hydrolysing) 50%
• Guanine 25%
• Gyrase Inhibitor 25%
• Malignant Neoplasm 75%
• Metastatic Melanoma 100%
• Overall Survival 25%
• Tumor Growth 25%