TY - JOUR
T1 - Clinical course and pharmacokinetics following a massive overdose of amphotericin b in a neonate
AU - Koren, Gideon
AU - Lau, Alan
AU - Kenyon, Cynthia F.
AU - Kroppert, David
AU - Klein, Julia
PY - 1990
Y1 - 1990
N2 - Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death (1). We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.
AB - Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death (1). We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.
UR - http://www.scopus.com/inward/record.url?scp=0025221340&partnerID=8YFLogxK
U2 - 10.3109/15563659008994438
DO - 10.3109/15563659008994438
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C2 - 2231836
AN - SCOPUS:0025221340
SN - 1556-3650
VL - 28
SP - 371
EP - 378
JO - Clinical Toxicology
JF - Clinical Toxicology
IS - 3
ER -