Capturing Subjective Mild Cognitive Decline in Parkinson’s Disease

This study aimed to capture subjective daily functional cognitive decline among patients with Parkinson's disease. Participants (40-79 y; 78 with Parkinson's disease and 41 healthy matched controls) completed the Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Parkinson's Disease Cognitive Functional Rating Scale (CFRS), Daily Living Questionnaire (DLQ), and Time Organisation and Participation Scale (TOPS) questionnaires. Patients with Parkinson's disease were divided into groups with or without suspected mild cognitive decline according to their scores on the Cognitive Functional (CF) feature, which is based on certain items of the MDS-UPDRS. Significant between-group differences were found in the DLQ and TOPS scores. Significant correlations were found among the questionnaire results, with specific DLQ and TOPS items accounting for 35% of the variance in the CF feature, which correlated with daily cognitive functional states. This study's results are relevant for detecting subtle deficits in Parkinson's disease patients suspected of mild cognitive decline, which can affect health and quality of life and relates to risk for later dementia.