Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations

Keyphrases

• Cancer Cells 100%
• Cell Response 100%
• Heat Shock Protein 70 (HSP70) 100%
• Hsp90 Inhibitor 100%
• Synergistic Drug Combination 100%
• HSP70 Inhibitor 100%
• Gene Expression 25%
• Signaling Pathway 25%
• Cancer Development 25%
• Anticancer Activity 25%
• Synergize 25%
• Cellular Physiology 25%
• Physiological Effects 25%
• Heat Shock Protein 90 (Hsp90) 25%
• Co-chaperone 25%
• Cancer Tumor 25%
• Cellular Response 25%
• Drug Combination 25%
• Cell-Associated 25%
• Unique Effects 25%
• Identified Genes 25%
• C-Myc 25%
• Preclinical Development 25%
• Multiple Effects 25%
• Connectivity Map 25%
• Potential Drugs 25%
• Tumor-associated Macrophages 25%
• Anticancer Target 25%

Biochemistry, Genetics and Molecular Biology

• Hsp70 100%
• Cancer Cell 100%
• Hsp90 Inhibitor 100%
• Protein Kinase B 25%
• Proteasome 12%
• Cell Function 12%
• Anticancer 12%
• Gene Expression 12%
• Hsp90 12%
• Antineoplastic Activity 12%
• Co-Chaperone 12%
• Tumor-Associated Macrophage 12%
• Preclinical Study 12%
• Oncogene C Myc 12%