Autoantibodies to DNA in multicase families with schizophrenia

Pinkhas Sirota, Michael A. Firer, Klara Schild, Amir Tanay, Avner Elizur, Dina Meytes, Hanoch Slor

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

46 ציטוטים ‏(Scopus)

תקציר

In an attempt to define the autoimmune status of members of multicase families with schizophrenia, sera of both patients and healthy relatives from 28 such cases were tested for antinuclear antibodies, anti-double-strandedDNA, and anti-single-strandedDNA autoantibodies. These autoantibodies were significantly more frequent in both schizophrenic patients and healthy relatives than in normal subjects. Immunoglobulin (Ig) M anti-DNA antibodies were more common in patients, whereas in healthy relatives, IgG anti-DNA antibodies were more common. No significant differences were found between schizophrenic patients and their healthy relatives. The data indicate that an autoimmune process may be involved in the etiology of a subset of patients with schizophrenia.

שפה מקוריתאנגלית
עמודים (מ-עד)450-455
מספר עמודים6
כתב עתBiological Psychiatry
כרך33
מספר גיליון6
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 15 מרץ 1993
פורסם באופן חיצוניכן

טביעת אצבע

להלן מוצגים תחומי המחקר של הפרסום 'Autoantibodies to DNA in multicase families with schizophrenia'. יחד הם יוצרים טביעת אצבע ייחודית.

פורמט ציטוט ביבליוגרפי