Aggregation induced emission “Turn on” ultra-low detection of anti-inflammatory drug flufenamic acid in human urine samples by carbon dots derived from bamboo stem waste

Subitha Adaikalapandi, T. Daniel Thangadurai, S. Sivakumar, D. Nataraj, Alex Schechter, Nandakumar Kalarikkal, Sabu Thomas

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Carbon dot-based fluorescence sensors have attracted research interest for the selective determination of anti-inflammatory drugs in biological fluids and environments. The overdose and accumulation of anti-inflammatory drugs in tissues can cause chronic side effects including abdominal pain, and renal damage. Herein, we report a new fluorescent probe, bamboo stem waste-derived carbon dots (BS-CDs) for highly sensitive detection of Flufenamic acid (FA), a hazardous anti-inflammatory drug. The UV–vis absorption spectra of BS-CDs show a redshifted absorption peak at 283 nm upon the addition of FA suggesting strong binding interaction between BS-CDs and FA molecule. The BS-CDs showed a fluorescence enhancement (∼2-fold) detection for FA (400 μM) in the linear concentration range (0.40 → 0.65 μM) with a limit of detection (LoD; 17 nM) and binding constant (Ka = 1.33 × 10−3 M−1). The time-resolved fluorescence decay analysis showed that the average lifetime of BS-CDs has slightly changed (4.42 → 4.67 ns) by the interaction with FA through the aggregation-induced emission (AIE) process. The interference, pH, and effect of time results suggest that BS-CDs are highly selective probes for FA detection and do not show any interference involvement during FA detection. The confirmation of the structure and morphology changes of BS-CDs after interaction with FA was carried out by XRD, FESEM, HRTEM, FTIR, and Raman spectroscopy. The practicability of the BS-CDs probe was proved by the detection of FA in human urine samples with recovery of 103–109 %. This suggests that the proposed BS-CDs-based ‘turn-on’ sensor could be used to determine the FA in biological fluids.

שפה מקוריתאנגלית
מספר המאמר125278
כתב עתSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
כרך326
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 5 פבר׳ 2025

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