תקציר
We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abortions. To the best of our knowledge, this is the first report of this translocation in a specific ethnic group. We conclude that the derivative chromosome 15 with chromosome Y is probably a normal variant in Ethiopian Beta Israel occurring at an estimated frequency of 4/74 (5.4%). The prenatal diagnosis of this translocation in this population probably does not require further parental testing.
שפה מקורית | אנגלית |
---|---|
עמודים (מ-עד) | 171-174 |
מספר עמודים | 4 |
כתב עת | Cytogenetic and Genome Research |
כרך | 136 |
מספר גיליון | 3 |
מזהי עצם דיגיטלי (DOIs) | |
סטטוס פרסום | פורסם - אפר׳ 2012 |
פורסם באופן חיצוני | כן |