A novel VIP responsive gene: Activity dependent neuroprotective protein

I. Gozes; R. Zamostiano; A. Pinhasov; M. Bassan; E. Giladi; R. A. Steingart; D. E. Brenneman

doi:10.1111/j.1749-6632.2000.tb06957.x

A novel VIP responsive gene: Activity dependent neuroprotective protein

I. Gozes
, R. Zamostiano
, A. Pinhasov
, M. Bassan
, E. Giladi
, R. A. Steingart
, D. E. Brenneman

פרסום מחקרי: פרסום בכתב עת › מאמר › ביקורת עמיתים

39 ציטוטים ‏(Scopus)

תקציר

Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.

שפה מקורית	אנגלית
עמודים (מ-עד)	115-118
מספר עמודים	4
כתב עת	Annals of the New York Academy of Sciences
כרך	921
מזהי עצם דיגיטלי (DOIs)	https://doi.org/10.1111/j.1749-6632.2000.tb06957.x
סטטוס פרסום	פורסם - 2000
פורסם באופן חיצוני	כן

גישה למסמך

10.1111/j.1749-6632.2000.tb06957.x

קבצים וקישורים אחרים

Link to publication in Scopus

פורמט ציטוט ביבליוגרפי

@article{727086b10b3c488382868b68ba9ed478,

title = "A novel VIP responsive gene: Activity dependent neuroprotective protein",

abstract = "Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.",

author = "I. Gozes and R. Zamostiano and A. Pinhasov and M. Bassan and E. Giladi and Steingart, \{R. A.\} and Brenneman, \{D. E.\}",

year = "2000",

doi = "10.1111/j.1749-6632.2000.tb06957.x",

language = "אנגלית",

volume = "921",

pages = "115--118",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - A novel VIP responsive gene

T2 - Activity dependent neuroprotective protein

AU - Gozes, I.

AU - Zamostiano, R.

AU - Pinhasov, A.

AU - Bassan, M.

AU - Giladi, E.

AU - Steingart, R. A.

AU - Brenneman, D. E.

PY - 2000

Y1 - 2000

N2 - Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.

AB - Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.

UR - https://www.scopus.com/pages/publications/0034508629

U2 - 10.1111/j.1749-6632.2000.tb06957.x

DO - 10.1111/j.1749-6632.2000.tb06957.x

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C2 - 11193814

AN - SCOPUS:0034508629

SN - 0077-8923

VL - 921

SP - 115

EP - 118

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

A novel VIP responsive gene: Activity dependent neuroprotective protein

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