What is unique about superoxide toxicity as compared to other biological reductants? - a hypothesis

Gidon Czapski; Sara Goldstein; Dan Meyerstein

doi:10.3109/10715768809055147

What is unique about superoxide toxicity as compared to other biological reductants? - a hypothesis

Gidon Czapski, Sara Goldstein, Dan Meyerstein

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Abstract

Usually the toxicity of superoxide is attributed lo its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species. As many other nontoxic biological reductants reduce metal compounds, we suggest that part of the mechanism of superoxide toxicity results from its ability to oxidize metal ions bound to biological targets, which subsequently degrade the target via an intramolecular electron Transfer reaction.

Original language	English
Pages (from-to)	231-236
Number of pages	6
Journal	Free Radical Research
Volume	4
Issue number	4
DOIs	https://doi.org/10.3109/10715768809055147
State	Published - 1988
Externally published	Yes

Keywords

Cu(III)
Fe(IV)
Haber-Weiss mechanism
OH
Superoxide

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10.3109/10715768809055147

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abstract = "Usually the toxicity of superoxide is attributed lo its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species. As many other nontoxic biological reductants reduce metal compounds, we suggest that part of the mechanism of superoxide toxicity results from its ability to oxidize metal ions bound to biological targets, which subsequently degrade the target via an intramolecular electron Transfer reaction.",

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AU - Goldstein, Sara

AU - Meyerstein, Dan

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N2 - Usually the toxicity of superoxide is attributed lo its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species. As many other nontoxic biological reductants reduce metal compounds, we suggest that part of the mechanism of superoxide toxicity results from its ability to oxidize metal ions bound to biological targets, which subsequently degrade the target via an intramolecular electron Transfer reaction.

AB - Usually the toxicity of superoxide is attributed lo its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species. As many other nontoxic biological reductants reduce metal compounds, we suggest that part of the mechanism of superoxide toxicity results from its ability to oxidize metal ions bound to biological targets, which subsequently degrade the target via an intramolecular electron Transfer reaction.

KW - Cu(III)

KW - Fe(IV)

KW - Haber-Weiss mechanism

KW - OH

KW - Superoxide

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What is unique about superoxide toxicity as compared to other biological reductants? - a hypothesis

Abstract

Keywords

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