Water exclusion and enantioselectivity in catalysis

Ronald Breslow; Subhajit Bandyopadhyay; Mindy Levine; Wenjun Zhou

doi:10.1002/cbic.200600120

Water exclusion and enantioselectivity in catalysis

Ronald Breslow
, Subhajit Bandyopadhyay
, Mindy Levine
, Wenjun Zhou

Research output: Contribution to journal › Short survey › peer-review

30 Scopus citations

Abstract

High and dry. Enzymes perform catalyses in the interior of the protein, which is not aqueous in character. Polyethylenimine enzyme mimics with a hydrophobic core also achieve high rates by excluding water. Two different approaches to the synthesis of such artificial enzymes with chirally attached side chains are described, as well as the use of these enzymes in performing biomimetic transaminations with chiral selectivity.

Original language	English
Pages (from-to)	1491-1496
Number of pages	6
Journal	ChemBioChem
Volume	7
Issue number	10
DOIs	https://doi.org/10.1002/cbic.200600120
State	Published - Oct 2006
Externally published	Yes

Keywords

Amino acids
Biomimetic synthesis
Meteorites polyethylenimines
Transamination

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10.1002/cbic.200600120

Cite this

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abstract = "High and dry. Enzymes perform catalyses in the interior of the protein, which is not aqueous in character. Polyethylenimine enzyme mimics with a hydrophobic core also achieve high rates by excluding water. Two different approaches to the synthesis of such artificial enzymes with chirally attached side chains are described, as well as the use of these enzymes in performing biomimetic transaminations with chiral selectivity.",

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AU - Levine, Mindy

AU - Zhou, Wenjun

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KW - Amino acids

KW - Biomimetic synthesis

KW - Meteorites polyethylenimines

KW - Transamination

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Water exclusion and enantioselectivity in catalysis

Abstract

Keywords

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