TY - JOUR
T1 - Water exclusion and enantioselectivity in catalysis
AU - Breslow, Ronald
AU - Bandyopadhyay, Subhajit
AU - Levine, Mindy
AU - Zhou, Wenjun
PY - 2006/10
Y1 - 2006/10
N2 - High and dry. Enzymes perform catalyses in the interior of the protein, which is not aqueous in character. Polyethylenimine enzyme mimics with a hydrophobic core also achieve high rates by excluding water. Two different approaches to the synthesis of such artificial enzymes with chirally attached side chains are described, as well as the use of these enzymes in performing biomimetic transaminations with chiral selectivity.
AB - High and dry. Enzymes perform catalyses in the interior of the protein, which is not aqueous in character. Polyethylenimine enzyme mimics with a hydrophobic core also achieve high rates by excluding water. Two different approaches to the synthesis of such artificial enzymes with chirally attached side chains are described, as well as the use of these enzymes in performing biomimetic transaminations with chiral selectivity.
KW - Amino acids
KW - Biomimetic synthesis
KW - Meteorites polyethylenimines
KW - Transamination
UR - http://www.scopus.com/inward/record.url?scp=33749675672&partnerID=8YFLogxK
U2 - 10.1002/cbic.200600120
DO - 10.1002/cbic.200600120
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C2 - 16977662
AN - SCOPUS:33749675672
SN - 1439-4227
VL - 7
SP - 1491
EP - 1496
JO - ChemBioChem
JF - ChemBioChem
IS - 10
ER -