Water exclusion and enantioselectivity in catalysis

Ronald Breslow, Subhajit Bandyopadhyay, Mindy Levine, Wenjun Zhou

Research output: Contribution to journalShort surveypeer-review

28 Scopus citations


High and dry. Enzymes perform catalyses in the interior of the protein, which is not aqueous in character. Polyethylenimine enzyme mimics with a hydrophobic core also achieve high rates by excluding water. Two different approaches to the synthesis of such artificial enzymes with chirally attached side chains are described, as well as the use of these enzymes in performing biomimetic transaminations with chiral selectivity.

Original languageEnglish
Pages (from-to)1491-1496
Number of pages6
Issue number10
StatePublished - Oct 2006
Externally publishedYes


  • Amino acids
  • Biomimetic synthesis
  • Meteorites polyethylenimines
  • Transamination


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