TY - JOUR
T1 - Variation of skeletal biomarkers of biological aging in a Chuvashian Population
T2 - A longitudinal study
AU - Kalichman, Leonid
AU - Malkin, Ida
AU - Livshits, Gregory
AU - Pavlovsky, Oleg
AU - Batsevich, Valery
AU - Kobyliansky, Eugene
PY - 2007/1
Y1 - 2007/1
N2 - Osseographic score (OSS) is a skeletal biomarker of biological aging, based on assessment of the hand's radiographic features. The aims of the present cross-sectional and follow-up study were: 1) to evaluate age-related changes of OSS in a large Chuvashian cohort, and 2) to evaluate sex differences in age-related changes of OSS. This study reports on intersexual differences in the pattern of skeletal aging. The most prominent difference was in the rate of skeletal change, measured as average OSS difference per year. However, no differences were found in the age at which the first skeletal change occurred. The mean values of OSS were higher in males than in females in decades 3-5 of life, but afterwards they reversed. In a follow-up study, we found that sex differences regarding the rate of OSS change began in the fifth decade, but became statistically significant only in the sixth and seventh decades. Thereafter, the rate of OSS change again became virtually equal between sexes.
AB - Osseographic score (OSS) is a skeletal biomarker of biological aging, based on assessment of the hand's radiographic features. The aims of the present cross-sectional and follow-up study were: 1) to evaluate age-related changes of OSS in a large Chuvashian cohort, and 2) to evaluate sex differences in age-related changes of OSS. This study reports on intersexual differences in the pattern of skeletal aging. The most prominent difference was in the rate of skeletal change, measured as average OSS difference per year. However, no differences were found in the age at which the first skeletal change occurred. The mean values of OSS were higher in males than in females in decades 3-5 of life, but afterwards they reversed. In a follow-up study, we found that sex differences regarding the rate of OSS change began in the fifth decade, but became statistically significant only in the sixth and seventh decades. Thereafter, the rate of OSS change again became virtually equal between sexes.
UR - http://www.scopus.com/inward/record.url?scp=33846033555&partnerID=8YFLogxK
U2 - 10.1002/ajhb.20582
DO - 10.1002/ajhb.20582
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C2 - 17160987
AN - SCOPUS:33846033555
SN - 1042-0533
VL - 19
SP - 74
EP - 81
JO - American Journal of Human Biology
JF - American Journal of Human Biology
IS - 1
ER -