TY - JOUR
T1 - Validation of self-reported smoking by analysis of hair for nicotine and cotinine
AU - Eliopoulos, Chrisoula
AU - Klein, Julia
AU - Koren, Gideon
PY - 1996
Y1 - 1996
N2 - Evidence suggesting the use of self-reports as an index of systemic exposure to cigarette smoke in selected study populations is highly inaccurate. In order to assess the use of hair analysis as a biochemical marker of cigarette smoking, we compared measurements of nicotine and cotinine in the hair and plasma of 36 volunteers whose reports of smoking were deemed to be reliable. A significant correlation was observed between the number of cigarettes smoked and hair measurements of nicotine (r = 0.48, p = 0.004) and cotinine (r = 0.57, p = 0.0008). In addition, a good correlation was found between the reported number of cigarettes smoked and plasma nicotine, plasma cotinine, and carboxyhemoglobin levels. These results suggest that hair analysis is a reliable noninvasive method of determining human exposure to cigarette smoke and is comparable to blood analysis.
AB - Evidence suggesting the use of self-reports as an index of systemic exposure to cigarette smoke in selected study populations is highly inaccurate. In order to assess the use of hair analysis as a biochemical marker of cigarette smoking, we compared measurements of nicotine and cotinine in the hair and plasma of 36 volunteers whose reports of smoking were deemed to be reliable. A significant correlation was observed between the number of cigarettes smoked and hair measurements of nicotine (r = 0.48, p = 0.004) and cotinine (r = 0.57, p = 0.0008). In addition, a good correlation was found between the reported number of cigarettes smoked and plasma nicotine, plasma cotinine, and carboxyhemoglobin levels. These results suggest that hair analysis is a reliable noninvasive method of determining human exposure to cigarette smoke and is comparable to blood analysis.
KW - Carbon monoxide
KW - Cotinine
KW - Hair
KW - Nicotine
KW - Pregnancy
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=0029740041&partnerID=8YFLogxK
U2 - 10.1097/00007691-199610000-00002
DO - 10.1097/00007691-199610000-00002
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C2 - 8885115
AN - SCOPUS:0029740041
SN - 0163-4356
VL - 18
SP - 532
EP - 536
JO - Therapeutic Drug Monitoring
JF - Therapeutic Drug Monitoring
IS - 5
ER -