Unintended pregnancy during radiotherapy for cancer

Saskia N. de Wildt; Nobuko Taguchi; Gideon Koren

doi:10.1038/ncponc1320

Unintended pregnancy during radiotherapy for cancer

Saskia N. de Wildt, Nobuko Taguchi, Gideon Koren

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: A 27-year-old woman with upper mediastinum stage IIA Hodgkin lymphoma was treated with six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Two months later she received a total of 4,250 cGy to the upper mediastinum and left clavicular region over a 1-month period. One week after completion of radiotherapy she was found to be 13-weeks pregnant. Her physician advised her to terminate pregnancy. She contacted a teratology information service for further information regarding the risks of radiation exposure for her fetus. Investigations: Estimation of fetal radiation exposure, literature review and synthesis of published cases and effects of fetal radiation exposure. Diagnosis: Estimated fetal radiation dose between 5 and 18 cGy. Management: Counseling on the possible risks to the fetus as a result of radiation exposure.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Nature Clinical Practice Oncology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1038/ncponc1320
State	Published - 2009
Externally published	Yes

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10.1038/ncponc1320

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@article{9275d65b257449d185153525d3610719,

title = "Unintended pregnancy during radiotherapy for cancer",

abstract = "Background: A 27-year-old woman with upper mediastinum stage IIA Hodgkin lymphoma was treated with six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Two months later she received a total of 4,250 cGy to the upper mediastinum and left clavicular region over a 1-month period. One week after completion of radiotherapy she was found to be 13-weeks pregnant. Her physician advised her to terminate pregnancy. She contacted a teratology information service for further information regarding the risks of radiation exposure for her fetus. Investigations: Estimation of fetal radiation exposure, literature review and synthesis of published cases and effects of fetal radiation exposure. Diagnosis: Estimated fetal radiation dose between 5 and 18 cGy. Management: Counseling on the possible risks to the fetus as a result of radiation exposure.",

author = "{de Wildt}, {Saskia N.} and Nobuko Taguchi and Gideon Koren",

note = "Funding Information: SN de Wildt{\textquoteright}s research is supported by a Ter Meulen Fund stipend from the Royal Netherlands Academy of Research, and a Restracomp grant from the Hospital for Sick Children, Toronto, Canada. N Taguchi{\textquoteright}s research is supported by the Aiiku Imperial Fund in Japan, and a Restracomp grant from the Hospital for Sick Children. G Koren is supported by the Research Leadership for Better Pharmacotherapy during Pregnancy and Lactation at the University of Toronto, and is a holder of the Ivey Chair in Molecular Toxicology, at the University of Western Ontario, Canada.",

year = "2009",

doi = "10.1038/ncponc1320",

language = "אנגלית",

volume = "6",

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T1 - Unintended pregnancy during radiotherapy for cancer

AU - de Wildt, Saskia N.

AU - Taguchi, Nobuko

AU - Koren, Gideon

N1 - Funding Information: SN de Wildt’s research is supported by a Ter Meulen Fund stipend from the Royal Netherlands Academy of Research, and a Restracomp grant from the Hospital for Sick Children, Toronto, Canada. N Taguchi’s research is supported by the Aiiku Imperial Fund in Japan, and a Restracomp grant from the Hospital for Sick Children. G Koren is supported by the Research Leadership for Better Pharmacotherapy during Pregnancy and Lactation at the University of Toronto, and is a holder of the Ivey Chair in Molecular Toxicology, at the University of Western Ontario, Canada.

PY - 2009

Y1 - 2009

N2 - Background: A 27-year-old woman with upper mediastinum stage IIA Hodgkin lymphoma was treated with six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Two months later she received a total of 4,250 cGy to the upper mediastinum and left clavicular region over a 1-month period. One week after completion of radiotherapy she was found to be 13-weeks pregnant. Her physician advised her to terminate pregnancy. She contacted a teratology information service for further information regarding the risks of radiation exposure for her fetus. Investigations: Estimation of fetal radiation exposure, literature review and synthesis of published cases and effects of fetal radiation exposure. Diagnosis: Estimated fetal radiation dose between 5 and 18 cGy. Management: Counseling on the possible risks to the fetus as a result of radiation exposure.

AB - Background: A 27-year-old woman with upper mediastinum stage IIA Hodgkin lymphoma was treated with six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy. Two months later she received a total of 4,250 cGy to the upper mediastinum and left clavicular region over a 1-month period. One week after completion of radiotherapy she was found to be 13-weeks pregnant. Her physician advised her to terminate pregnancy. She contacted a teratology information service for further information regarding the risks of radiation exposure for her fetus. Investigations: Estimation of fetal radiation exposure, literature review and synthesis of published cases and effects of fetal radiation exposure. Diagnosis: Estimated fetal radiation dose between 5 and 18 cGy. Management: Counseling on the possible risks to the fetus as a result of radiation exposure.

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EP - 178

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JF - Nature Clinical Practice Oncology

IS - 3

ER -

Unintended pregnancy during radiotherapy for cancer

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