Ultrasound mediated transdermal drug delivery

Aharon Azagury, Luai Khoury, Giora Enden, Joseph Kost

Research output: Contribution to journalReview articlepeer-review

211 Scopus citations


Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin. Application of ultrasound (US) irradiation to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis in transdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field. Particular attention is paid to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy.

Original languageEnglish
Pages (from-to)127-143
Number of pages17
JournalAdvanced Drug Delivery Reviews
StatePublished - 15 Jun 2014
Externally publishedYes


  • Models and simulations
  • Safety
  • Sonophoresis
  • Synergistic effects of ultrasound
  • Transdermal drug delivery
  • Transport phenomena
  • Ultrasound


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