Type II diabetes mellitus, congestive heart failure, and zinc metabolism

Ahuva Golik, Nathan Cohen, Yoram Ramot, Joseph Maor, Rita Moses, Joshua Weissgarten, Yuval Leonov, David Modai

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47 Scopus citations

Abstract

Zinc status was assessed in patients with type II diabetes mellitus and congestive heart failure (CHF). Three groups of patients were enrolled into the study: Group 1: 15 patients with type II diabetes mellitus and CHF; Group 2: 20 patients with isolated type II diabetes mellitus; and Group 3: nine patients with isolated CHF. Twenty-four-hour urine was measured for creatinine, protein, and zinc, and blood was drawn for creatinine, proteins, liver enzymes, hemoglobin A1c, and zinc. Insulin treatment and hemoglobin A1c were comparable in the diabetic patients of groups 1 and 2, but group 1 was also treated with captopril and diuretics like the CHF patients of group 3. Plasma zinc levels were statistically similar in all three groups, but urinary zinc excretion (μmol/24 h) and urinary zinc: creatinine (μmol/mmol) ratio were significantly higher in the type II diabetics and CHF group (27.2±1.5; 1.69±0.6, respectively) compared to the diabetic patients alone (19.4±0.76; 0.97±0.3, respectively) and the CHF patients (9.7±0.3; 0.62±0.3, respectively). Patients with type II diabetes mellitus and CHF were treated with higher doses of captopril than the CHF patients (56.25±24 mg vs 18.8±11 mg P<0.05). Thus, patients with type II diabetes mellitus and CHF excrete larger amounts of zinc, which may eventually lead to zinc deficiency.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalBiological Trace Element Research
Volume39
Issue number2-3
DOIs
StatePublished - Nov 1993
Externally publishedYes

Keywords

  • Congestive heart failure
  • plasma zinc
  • type II diabetes mellitus
  • urine zinc

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