Transient hepatocellular injury during attacks of cholinergic urticaria

Y. Niv, I. Elkan, G. M. Fraser

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Cholinergic urticaria presents as wheals and erythroderma that develop in response to a variety of factors which stimulate muscarinic receptors, including exercise, heat, cold, sweat and emotional stress. We describe a 25-year-old man with ulcerative colitis who developed cholinergic urticaria diagnosed by a metacholine test. He had had seven previous attacks over 8 years, and the finding of elevated liver enzymes required admission to four different hospitals. The clinical picture was identical: urticaria, hepatosplenomegaly, lymphadenopathy and elevation of liver enzymes. The causative agent was never identified and recovery was complete, with or without antibiotic therapy. To the best of our knowledge, this is the first description of liver involvement in cholinergic urticaria noted in the English-language medical literature.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
JournalIsrael Journal of Medical Sciences
Issue number1
StatePublished - Jan 1997
Externally publishedYes


  • Acetylcholine
  • Allergy
  • Histamine
  • Liver function tests
  • Urticaria


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