Toxic neonatal effects following maternal clomipramine therapy

Michael S. Schimmell; Ester Zylber Katz; Yechezkel Shaag; Anne Pastuszak; Gideon Koren

doi:10.3109/15563659109025744

Toxic neonatal effects following maternal clomipramine therapy

Michael S. Schimmell, Ester Zylber Katz, Yechezkel Shaag, Anne Pastuszak, Gideon Koren

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1). The drug is widely prescribed in Europe and Canada and has been recently approved for use in the USA. Its safety during pregnancy and breastfeeding, however, has not been fully established. Very few reports on its effect on the fetus and neonate have been published (2,3). We report a case of a mother treated with clomipramine during pregnancy, and the side effects observed in the infant. The correlation between plasma clomipramine concentrations in the baby's blood and clinical effects are described. Subsequently, we present the pregnancy outcome of five prospectively collected cases.

Original language	English
Pages (from-to)	479-484
Number of pages	6
Journal	Clinical Toxicology
Volume	29
Issue number	4
DOIs	https://doi.org/10.3109/15563659109025744
State	Published - 1991
Externally published	Yes

Keywords

Clomipramine
Human
In utero toxicity
Milk
Pregnancy
Tricyclic antidepressant

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10.3109/15563659109025744

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AU - Shaag, Yechezkel

AU - Pastuszak, Anne

AU - Koren, Gideon

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AB - Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1). The drug is widely prescribed in Europe and Canada and has been recently approved for use in the USA. Its safety during pregnancy and breastfeeding, however, has not been fully established. Very few reports on its effect on the fetus and neonate have been published (2,3). We report a case of a mother treated with clomipramine during pregnancy, and the side effects observed in the infant. The correlation between plasma clomipramine concentrations in the baby's blood and clinical effects are described. Subsequently, we present the pregnancy outcome of five prospectively collected cases.

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Toxic neonatal effects following maternal clomipramine therapy

Abstract

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