TY - JOUR
T1 - Tissue distribution of 2- and 4-[203Hg]-estradiol in mammary-tumor-bearing rats
AU - Shani, J.
AU - Lieberman, L. M.
AU - Samuni, A.
AU - Schlesinger, T.
AU - Cats, M.
N1 - Funding Information:
Acknowledgements---The authors wish to acknowledge the financial support from the following sources: IN-35 to the University of Wisconsin from the American Cancer Society; International Society Against Cancer; Wisconsin Clinical Cancer Center and the University of Wisconsin Hospital-Department of Radiology. Research and Development Fund. The authors also wish to thank Dr John A. Katzenellenbogen for his valuable remarks.
PY - 1982
Y1 - 1982
N2 - The newly synthesized 2-[203 Hg]-estradiol-17β and 4-[203Hg]-estradiol-17β were injected into Fischer female rats bearing transplanted mammary adenocarcinomas and into Sprague -Dawley female rats bearing spontaneous mammary tumors. Four days after injection, tumor to blood ratios (and uterine to blood ratios) in the various groups were between 5 and 14, compared to a ratio of unity observed in normal mammary glands. When injected into male rats, the accumulation of 4-[203Hg]-estradiol in the prostate and in the epididimis was very low. With minute doses of 4-[203Hg]-estradiol injected into healthy male rats, the whole-body retention of the drug was found to decrease exponentially with time, and biphasic first order kinetics were observed. With pharmacological doses of the same drug, the clearance exhibited a biphasic pattern.
AB - The newly synthesized 2-[203 Hg]-estradiol-17β and 4-[203Hg]-estradiol-17β were injected into Fischer female rats bearing transplanted mammary adenocarcinomas and into Sprague -Dawley female rats bearing spontaneous mammary tumors. Four days after injection, tumor to blood ratios (and uterine to blood ratios) in the various groups were between 5 and 14, compared to a ratio of unity observed in normal mammary glands. When injected into male rats, the accumulation of 4-[203Hg]-estradiol in the prostate and in the epididimis was very low. With minute doses of 4-[203Hg]-estradiol injected into healthy male rats, the whole-body retention of the drug was found to decrease exponentially with time, and biphasic first order kinetics were observed. With pharmacological doses of the same drug, the clearance exhibited a biphasic pattern.
UR - http://www.scopus.com/inward/record.url?scp=0020456636&partnerID=8YFLogxK
U2 - 10.1016/0047-0740(82)90085-7
DO - 10.1016/0047-0740(82)90085-7
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C2 - 7186497
AN - SCOPUS:0020456636
SN - 0047-0740
VL - 9
SP - 251
EP - 258
JO - International Journal of Nuclear Medicine and Biology
JF - International Journal of Nuclear Medicine and Biology
IS - 4
ER -