Tissue- and species-dependent expression of sheep lung microsomal cytochrome P4502B(LgM2)

E. Arinc, I. Hanukoglu, A. Sen, O. Adali

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Expression of sheep lung microsomal cytochrome P4502B(LgM2) isozyme was determined in lung and liver preparations from rabbits, rats, sheep, cows and humans. Several tissues of sheep such as lung, liver, adrenal, kidney, ovary, intestine, muscle, spleen, pancreas and brain were also examined. Tissue homogenates were analyzed by Western-blotting with an antibody raised against purified sheep lung P4502B(LgM2) isozyme in rabbits. This isozyme was detected in lung samples from every species examined. Homologues of cytochrome P4502B(LgM2) were expressed in livers of sheep and rabbits but not in those of humans and cows. Although homologous forms of P4502B(LgM2) were not expressed in sheep brain, ovary, pancreas, spleen and muscle tissues, they were expressed in sheep adrenal, intestine and kidney.

Original languageEnglish
Pages (from-to)1121-1126
Number of pages6
JournalBiochemistry and Molecular Biology International
Volume37
Issue number6
StatePublished - 1995
Externally publishedYes

Keywords

  • Cytochrome P3502B(LgM2)
  • Homologues
  • Lung microsomes
  • Sheep tissues

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