Tibial hemimelia and tetralogy of fallot associated with first trimester exposure to amantadine

Paresh B. Pandit; David Chitayat; Ann L. Jefferies; Allison Landes; Izhar U. Qamar; Gideon Koren

doi:10.1016/0890-6238(94)90072-8

Tibial hemimelia and tetralogy of fallot associated with first trimester exposure to amantadine

Paresh B. Pandit, David Chitayat, Ann L. Jefferies, Allison Landes, Izhar U. Qamar, Gideon Koren

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19 Scopus citations

Abstract

Although amantadine hydrochloride has been extensively used for the prevention of influenza A2, few data exist regarding its safety in pregnancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 29 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follow-up of the four prospective cases known to date to the Motherisk Program in Toronto did not identify any abnormalities.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	Reproductive Toxicology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/0890-6238(94)90072-8
State	Published - 1994
Externally published	Yes

Keywords

amantadine
parainfluenza
pregnancy
tetralogy of Fallot
tetratogens
tibial hemimelia

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10.1016/0890-6238(94)90072-8

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title = "Tibial hemimelia and tetralogy of fallot associated with first trimester exposure to amantadine",

abstract = "Although amantadine hydrochloride has been extensively used for the prevention of influenza A2, few data exist regarding its safety in pregnancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 29 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follow-up of the four prospective cases known to date to the Motherisk Program in Toronto did not identify any abnormalities.",

keywords = "amantadine, parainfluenza, pregnancy, tetralogy of Fallot, tetratogens, tibial hemimelia",

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AU - Pandit, Paresh B.

AU - Chitayat, David

AU - Jefferies, Ann L.

AU - Landes, Allison

AU - Qamar, Izhar U.

AU - Koren, Gideon

PY - 1994

Y1 - 1994

N2 - Although amantadine hydrochloride has been extensively used for the prevention of influenza A2, few data exist regarding its safety in pregnancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 29 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follow-up of the four prospective cases known to date to the Motherisk Program in Toronto did not identify any abnormalities.

AB - Although amantadine hydrochloride has been extensively used for the prevention of influenza A2, few data exist regarding its safety in pregnancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 29 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follow-up of the four prospective cases known to date to the Motherisk Program in Toronto did not identify any abnormalities.

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KW - parainfluenza

KW - pregnancy

KW - tetralogy of Fallot

KW - tetratogens

KW - tibial hemimelia

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Tibial hemimelia and tetralogy of fallot associated with first trimester exposure to amantadine

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