TY - JOUR
T1 - Therapeutic Choices for Nausea and Vomiting of Pregnancy
T2 - A Critical Review of a Systematic Review
AU - Koren, Gideon
AU - Maltepe, Caroline
AU - Gow, Rachel
N1 - Publisher Copyright:
© 2011 Society of Obstetricians and Gynaecologists of Canada.
PY - 2011
Y1 - 2011
N2 - With 80% of pregnant women suffering from some degree of "morning sickness," or nausea and vomiting of pregnancy (NVP), symptom management is a major challenge. A recent Cochrane systematic review of randomized controlled trials concluded that, to date, there is no strong evidence of effectiveness for practically any therapeutic agent used for management of NVP. Because of fears of teratogenicity and litigation, RCTs are rarely conducted in pregnancy. In the absence of the best possible evidence from RCTs, well planned and executed prospective observational studies should be used as the best available evidence to guide clinical practice.
AB - With 80% of pregnant women suffering from some degree of "morning sickness," or nausea and vomiting of pregnancy (NVP), symptom management is a major challenge. A recent Cochrane systematic review of randomized controlled trials concluded that, to date, there is no strong evidence of effectiveness for practically any therapeutic agent used for management of NVP. Because of fears of teratogenicity and litigation, RCTs are rarely conducted in pregnancy. In the absence of the best possible evidence from RCTs, well planned and executed prospective observational studies should be used as the best available evidence to guide clinical practice.
KW - Antiemetics
KW - Morning sickness
KW - NVP
KW - Nausea and vomiting of pregnancy
KW - Prospective observational studies
UR - http://www.scopus.com/inward/record.url?scp=82255172016&partnerID=8YFLogxK
U2 - 10.1016/S1701-2163(16)34960-X
DO - 10.1016/S1701-2163(16)34960-X
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C2 - 21749751
AN - SCOPUS:82255172016
SN - 1701-2163
VL - 33
SP - 733
EP - 735
JO - Journal of Obstetrics and Gynaecology Canada
JF - Journal of Obstetrics and Gynaecology Canada
IS - 7
ER -