Abstract
The influence of 3-9 months of combined low dose oral contraceptives on theophylline pharmacokinetics was studied in 10 adolescent females (age 15-18 years, mean ± SD 17 ± 1) and compared to 10 age-matched control subjects (age 13.8-19 years, mean ± SD 16.5 ± 1.6). The distribution volume (0.44 ± 0.06 L/kg in control vs. 0.44 ± 0.09 L/kg oral contraceptive group), total body clearance (0.78 ± 0.13 ml/kg/min vs 0.78 ± 0.18 ml/kg/min) and elimination T 1/2 (402 ± 78 min vs. 409 ± 126 min) were identical in the two groups. It appears that during the first 3-9 months of low dose oral contraceptive treatment, these steroids do not alter the pharmacokinetic behaviour of theophylline in adolescent females.
| Original language | English |
|---|---|
| Pages (from-to) | 222-226 |
| Number of pages | 5 |
| Journal | Clinical and Investigative Medicine |
| Volume | 8 |
| Issue number | 3 |
| State | Published - 1985 |
| Externally published | Yes |